Phosphatidic acid: a lipid regulator of the Hippo pathway
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چکیده
منابع مشابه
Okadaic Acid: A Tool to Study the Hippo Pathway
Mammalian Ste20-like kinases 1 and 2 (MST1 and MST2) are activated in NIH3T3 cells exposed to okadaic acid. The Hippo pathway is a newly emerging signaling that functions as a tumor suppressor. MST1 and MST2 work as core kinases of the Hippo pathway and their activities depend on the autophosphorylation, which is negatively regulated by protein phosphatase 2A (PP2A). Okadaic acid has been frequ...
متن کاملThe hippo pathway.
The Hippo pathway (Fig. 1), also known as the SalvadorWarts-Hippo pathway, regulates tissue growth in a wide variety of organisms (Harvey and Tapon 2007; Grusche et al. 2010; Oh and Irvine 2010; Pan 2010; Halder and Johnson 2011; Zhao et al. 2011). Many components of the pathway were identified as a result of mutations in the fruit fly Drosophila melanogaster that resulted in tissue overgrowth ...
متن کاملPulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase.
The lung contains two distinct forms of phosphatidic acid phosphatase (PAP). PAP1 is a cytosolic enzyme that is activated through fatty acid-induced translocation to the endoplasmic reticulum, where it converts phosphatidic acid (PA) to diacylglycerol (DAG) for the biosynthesis of phospholipids and neutral lipids. PAP1 is Mg(2+) dependent and sulfhydryl reagent sensitive. PAP2 is a six-transmem...
متن کاملPhosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis.
PA2 phosphatase (PAP3; 3-sn-phosphatidate phosphohydrolase, EC 3.1.3.4) catalyzes the Mg2 -dependent dephosphorylation of PA, yielding DAG and Pi (Fig. 1) (1–3). In de novo lipid synthesis, the DAG generated from the PAP reaction is utilized for the synthesis of the phospholipids PE and PC via the Kennedy pathway and for the synthesis of TAG (Fig. 1) (3). The enzyme substrate PA is also used fo...
متن کاملA Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets
Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of lipids. Little is known about how the size of LDs is controlled, although LDs of diverse sizes have been observed in different tissues and under different (patho)physiological conditions. Recent studies have indicated that the size of LDs may influence adipogenesis, the rate of lipolysis and the oxida...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2018
ISSN: 2372-3556
DOI: 10.1080/23723556.2018.1558683